Impact of Low Sodium Oxybate on Total Sleep Time in Patients with Idiopathic Hypersomnia

Purpose: Stanford University and Mayo Clinic have partnered to evaluate the efficacy of low sodium oxybate on total sleep time in patients with idiopathic hypersomnia. The comprehensive assessments will yield detailed information about how low sodium oxybate affects sleep, breathing, and other physiological metrics, ultimately enhancing understanding of idiopathic hypersomnia. 


  • Must be willing to come to Redwood City, Ca for study visits
  • Primary diagnosis of IH, according to ICSD-3 criteria (does not require MSLT)
  • Has been prescribed, or at least recommended to start low sodium oxybate
  • Must be 18 – 65 years old
  • BMI between 18 and 35 kg/m2
  • Self-reported sleep duration of ≥ 10 hours


  • Succinic semialdehyde dehydrogenase deficiency, porphyria.
  • Central nervous system diseases, cardiovascular disease, compromised respiratory function, malignant neoplastic disease requiring therapy, renal or hepatic impairment, and/or diagnosis of sleep-related breathing disorders 
  • Lifetime history of suicide attempt or suicidal ideation in the past 6 months
  • Change to psychiatric medication(s)/stimulant(s) within last 3 months.
  • No regular sleep at night: shift work or other continuous, non-disease-related life conditions.

Time commitment: We anticipate that the entire study will take 3 to 5 months to complete and the participant will need to visit the Redwood City Sleep Clinic a total of 6 to 7 times. These visits will involve two 24-hour sleep studies in the sleep lap, actigraphy monitoring, two blood draws, and various other activities that will be conducted during your appointments. Participants will be compensated for their time and effort.

Coordinator Contact: If you feel that you may be a good fit for this study, please fill out the prescreening questionnaire at this link: https://redcap.link/stanford.IHsleepstudy If you are interested in participating in this study, please email bdevera@stanford.edu with any questions.