What Is A Clinical Trial?

A clinical trial is any research study that evaluates interventions to prevent, detect, diagnose, or treat a disease or disorder. In a clinical trial, human participants (or groups of participants) are assigned to one or more interventions to assess the results on health outcomes.

Why Are Clinical Trials Important?

Clinical Trials are important in discovering new treatments to prevent, detect, diagnose or treat Narcolepsy. It is the only process to bring new pharmacological drugs and treatments forward for approval to use within the Narcolepsy community. Without the clinical trials, there is a risk that individuals could be given treatments which have no advantage, waste time and could even be harmful to one’s health. If a treatment has no benefit, or has serious side effects, the treatment may not be further developed.

Ongoing Research

Clinical Trial

Recruiting research participants diagnosed with narcolepsy type 2

Biotrial is collaborating with Alkermes to recruit individuals diagnosed with narcolepsy type 2 to participate in a research study to assess the proof of concept, safety, and tolerability of an investigational study drug, an orexin-2 receptor agonist.

Jazz DUET Study: Effective treatment and reduced sodium intake may work in perfect harmony

The DUET Study will evaluate daytime and nighttime effects of XYWAV® (low-sodium oxybate oral solution), also known as JZP258, in people with idiopathic hypersomnia (IH) or narcolepsy (Type 1 or Type 2).

XYLO Study: A clinical study looking at blood pressure in people with narcolepsy

This is a study looking at blood pressure in people with narcolepsy. We want to understand more about blood pressure when people with narcolepsy change from a high-sodium oxybate medication, like XYREM, to the study medication, XYWAV. XYWAV has the same active ingredients as XYREM, but with a much lower sodium content.

Recruiting Participants for the SYMPHONY Study

Falling asleep during the day? Sudden muscle weakness? Wake Up Narcolepsy is collaborating with Axsome Therapeutics on a study to assess the efficacy and safety of AXS-12 (Reboxetine) in patients with narcolepsy (SYMPHONY).

Polaris Clinical Development Program

Find out how you and other people with narcolepsy may benefit from the outcome of the POLARIS studies.

Research Study

IQVIA Survey and Interviews in Narcolepsy and IH with Xywav

IQVIA is currently looking for adults (≥18 years of age) who have been diagnosed with narcolepsy or IH currently taking Xywav® to take part in a paid research study.

Narcolepsy & Physical Activity Survey

Looking for participants with narcolepsy to complete a survey for a Grand State Valley University graduate study.

Psychometric Validation Study of three Patient-Reported Outcome Measures for Narcolepsy (NT2) in the United States

Pathophysiology of Narcolepsy and Idiopathic Hypersomnia: A Multimodal Neuroimaging Study

The research includes an MRI scan session and two (non-consecutive) overnight sleep sessions at our sleep laboratory in Montreal, Canada.

Hypersomnia and Narcolepsy Study is Recruiting Participants

There is a new clinical trial opportunity for PWNs located in Canada.

Fortrea Interview Study of Fatigue in Narcolepsy

CATNAP® Pediatric Narcolepsy Registry

Fact Sheet – Risk Evaluation and Mitigation Strategy (REMS) Programs to Promote Appropriate Medication Use and Knowledge: Patient Experiences with REMS Programs

Pillar Patient Advocates Survey

Participants paid $50.

Boston Children’s Hospital Narcolepsy Research Study for Kids Ages 9 to 17

Validation of Pediatric Narcolepsy Patient Reported Outcomes (PN-PROS)

Canadian Sleep Society: Recruitment of 1000 Families of Children Who Experience Sleeping Problems

Scaling-out Better Nights, Better Days to help children and families go from surviving to thriving during COVID-19.

Patient Experience in Clinical Trials Survey

Please help us improve the clinical trial for patients.

Recruiting Participants with Excessive Sleepiness

WUN is collaborating with Hypersomnia Foundation and Dr. Thanh Dang-Vu to investigate brain regions underlying narcolepsy (with or without cataplexy) and idiopathic hypersomnia.


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