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Narcolepsy Type 1: Orexin Agonist Restoration

Because partial or complete Orexin receptor deficiency plays an important role in the development of EDS, orexin replacement therapy may improve EDS through a pathophysiology-directed mechanism of action. We are currently investigating a new novel drug that acts to help address the deficiency of orexin-2 receptor agonists that may address the spectrum of narcolepsy symptoms and have greater efficacy than currently approved drugs for EDS and cataplexy.

Study Details

  • A phase-2, Randomized, double-blind clinical research study
  • Participants will last up to approximately 14 weeks with an optional adjusted dose 7 week extension
  • All participants will stop narcolepsy symptoms medications for at least 14 days prior to study start day and for the duration of the study.
  • 7-9 mandatory visits at our clinic
  • 2 mandatory overnight visits at our clinic’s newly renovated sleep lab suites
  • Eligible subjects receive compensation for their time and participation

If you are interested in learning more or want to participate, please visit Current Clinical Trials | Intrepid Research (intrepidresearchoh.com)