Feb 15 2024
Future Neurology Plain Language Summary (PLS) “Low Sodium Oxybate Improved Symptoms in Adults with Narcolepsy with Cataplexy”

Richard K Bogan, Nancy Foldvary-Schaefer, Wayne Macfadden, Monica Gow and Michael J Thorpy

“This plain language summary describes a clinical study that looked at the effects of a medicine called low-sodium oxybate (or LXB; XYWAV® [calcium, magnesium, potassium, and sodium oxybates]) in adults with narcolepsy. Narcolepsy is a rare brain disorder that can make people feel extremely sleepy during the day or have symptoms like cataplexy, which is sudden and temporary muscle weakness. This study compared changes in symptoms between people who either switched to placebo or continued with LXB after they had been taking LXB for 14 weeks. The placebo looked and tasted like LXB but did not have the active ingredient. This allowed researchers to see if LXB improved symptoms like cataplexy and extreme daytime sleepiness.”

Check out the full summary as a PDF here or view it online.