Apr 30 2025
Future Neurology “Effects of oxybate dose and regimen on disrupted nighttime sleep and sleep architecture: A Plain Language Summary”

Thomas Roth, Yves Dauvilliers, Richard K. Bogan, Giuseppe Plazzi, Monica Gow & Jed Black

“This is a plain language summary of a review article that looked at how different forms of a medicine called oxybate impact sleep in people with narcolepsy. People with narcolepsy often struggle with their sleep. They experience issues like sleep fragmentation or reduced sleep efficiency that may lead to poor sleep quality and disrupted nighttime sleep. To help people with these challenges, oxybate is used to improve sleep and also treat daytime symptoms of narcolepsy (such as excessive daytime sleepiness and cataplexy). Sodium oxybate (SXB; Xyrem®) was first approved in 2002, as a twice-nightly treatment. Newer versions of this medicine have been developed including once-nightly sodium oxybate (ON-SXB; Lumryz™) that contains the same amount of sodium and is taken once per night, and low-sodium oxybate (LXB; Xywav®), which is taken twice per night and has 92% less sodium than SXB. There have not been any direct studies comparing these different oxybate medicines. Information gathered from 5 clinical studies, along with additional supporting research, shows that taking oxybate at night can improve sleep quality and reduce sleep disturbances during the night for people with narcolepsy.”

Check out the full summary here.